33 research outputs found
Enhanced performance simulation of diesel engines
SIGLEAvailable from British Library Document Supply Centre- DSC:DX90577 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
State of nature 2019
State of Nature 2019 presents an overview of how the country’s wildlife is faring, looking back over nearly 50 years of monitoring to see how nature has changed in the UK, its Crown Dependencies and Overseas Territories. As well as this long-term view, we focus on what has happened in the last decade, and so whether things are getting better or worse for nature. In addition, we have assessed the pressures that are acting on nature, and the responses being made, collectively, to counter these pressures
State of nature 2023
This is the fourth State of Nature Report. It provides a comprehensive overview of species trends across the UK, including specific assessments for England, Northern Ireland, Scotland and Wales, and for the UK’s Overseas Territories
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
State of nature
For the first time ever, the UK’s
wildlife organisations have
joined forces to undertake a
health check of nature in the
UK and its Overseas Territories. 60% of the 3,148 UK species we assessed
have declined over the last 50 years and
31% have declined strongly.
Half of the species assessed have shown
strong changes in their numbers or range,
indicating that recent environmental
changes are having a dramatic impact
on nature in the UK. Species with specific
habitat requirements seem to be faring
worse than generalist species.
A new Watchlist Indicator, developed
to measure how conservation priority
species are faring, shows that their
overall numbers have declined by 77%
in the last 40 years, with little sign
of recovery.
Of more than 6,000 species that have
been assessed using modern Red List
criteria, more than one in 10 are thought
to be under threat of extinction in the UK.
Our assessment looks back over 50 years
at most, yet there were large declines in
the UK’s wildlife prior to this, linked to
habitat loss.
The UK’s Overseas Territories hold a
wealth of wildlife of huge international
importance and over 90 of these species
are at high risk of global extinction.
There is a lack of knowledge on the
trends of most of the UK’s species.
As a result, we can report quantitative
trends for only 5% of the 59,000 or so
terrestrial and freshwater species in
the UK, and for very few of the 8,500
marine species. Much needs to be done
to improve our knowledge.
What we do know about the state of
the UK’s nature is often based upon
the efforts of thousands of dedicated
volunteer enthusiasts who contribute
their time and expertise to monitoring
schemes and species recording.
The threats to the UK’s wildlife are
many and varied, the most severe
acting either to destroy valuable habitat
or degrade the quality and value of
what remains.
Climate change is having an increasing
impact on nature in the UK. Rising
average temperatures are known to be
driving range expansion in some species,
but evidence for harmful impacts is
also mounting.
The full report is online:
www.rspb.org.uk/stateofnature
We should act to save nature both for
its intrinsic value and for the benefits
it brings to us that are essential to our
wellbeing and prosperity.
Targeted conservation has produced
inspiring success stories and, with
sufficient determination, resources
and public support, we can turn the
fortunes of our wildlife around.
The State of Nature report serves
to illustrate that with shared resolve
and commitment we can save nature